科研动态

布鲁氏菌病的早期诊断及鉴定是该病防控的重要环节，其诊断技术主要包括细菌学诊断技术、血清学诊断技术以及分子生物学诊断技术。布鲁氏菌病防控应坚持预防为主的策略，其免疫主要以弱毒活疫苗为主，随着分子生物学及重组DNA技术的发展，基因工程疫苗成为近年研究热点，但目前尚未有鉴别疫苗免疫和自然感染的鉴别诊断技术及相应的疫苗制品。本文对布鲁氏菌病的病原学、流行病学、诊断技术和疫苗研究进展等方面进行概述，以期为建立灵敏性高、特异性强、高效便捷且易推广的布鲁氏菌病诊断技术和研发更加安全有效的布鲁氏菌病疫苗提供基础。

Research Progress on Brucellosis

It is the key to prevent and control brucellosis by early diagnosis and identification that mainly include the technologies of bacteriology，serology and molecular biology. The brucellosis vaccines have been playing an important role due to the strategy of“Prevention First”，and the live attenuated vaccines are commonly used at present. With the development of molecular biology and recombinant DNA technology，genetic engineering vaccine has developed rapidly and become a hotspot in recent years. However，no any differential diagnosis technologies and corresponding vaccine products for distinguishing vaccine immunity from natural infection have been available. In this paper，the etiology，epidemiology，diagnosis technology and brucellosis vaccine development status were summarized，which laid a foundation for the establishment of a popularized diagnosis technology with high sensitivity，specificity and efficiency，as well as for the development of the more effective and safer vaccines.

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