科研动态

禽星状病毒（avian astrovirus，AAstV）属于星状病毒科，包含多种亚型，可以引发禽肾炎、鸭肝炎以及火鸡腹泻等多种疾病，禽类感染后表现生长发育迟缓、产蛋下降，严重时可导致死亡，给养殖业造成一定的损失。此外，AAstV具有感染人的潜在风险。目前AAstV的致病机理暂不清楚，只有火鸡星状病毒引发肠炎的致病机制可作为参考。许多方法已用于AAstV检测，如电镜检测、酶联免疫吸附试验、细胞培养和病毒分离以及分子技术检测等。AAstV亚型较多，疫苗和药物研发存在较大难度，给该病防治带来一定的挑战。本文围绕AAstV的病原学、国内外流行情况、感染后临床症状及致病机制以及检测方法和控制措施等进行了综述，以期为后期进一步研究提供参考。

Advances in the Researches on Avian Astrovirus

Avian astrovirus（AAstV），a member of astroviridae family，includes a variety of subtypes，which may lead to avian nephritis，duck hepatitis，turkey diarrhea and other diseases. Such symptoms as growth retardation and decline in egg production even death may be observed in infected poultry，which would bring certain losses to breeding industry. In addition，the virus may bring potential risk to human. However，its pathogenic mechanism has been unknown，except the one for enteritis caused by Turkey astrovirus that may be used as a reference. The virus may be detected by many methods，such as electron microscopy，enzyme-linked immunosorbent assay（ELISA），cell culture and virus isolation，molecular technology，etc. However，it would be difficult to develop vaccines or drugs due to many subtypes，which brings certain challenges to the prevention and treatment of the disease. In the paper，the etiology，epidemic status all over the world，clinical symptoms，pathogenic mechanism，detection methods and countermeasures were summarized，so as to provide a reference for further researches in the future.

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