科研动态

呋喃西林是一种硝基呋喃类抗菌药物，曾被广泛应用于水产养殖过程中。呋喃西林在动物体内的代谢物氨基脲（SEM）会与细胞膜蛋白紧密结合，形成结合态残留物，稳定而长期存在于动物体内，具有致癌、致畸性。本文简要介绍了呋喃西林药物的药理作用及其应用，综述了两种应用于SEM检测的主要方法——高效液相色谱（HPLC）及其联用技术和免疫分析法的研究进展情况及其优缺点，以及食品中的SEM来源，以期对呋喃西林药物及其代谢物SEM有一个较为完整的了解，也为进一步开展相关研究奠定理论基础。

Research Progress on Nitrofurazone and Its Metabolite ofSemicarbazide in Animal-derived Food

Nitrofurazone，as anitrofuran antibiotic，had been widely used inaquaculture. However，the semicarbazide（SEM），a kind of metabolite generated bynitrofurazone within animal's body，could closelyincorporate with cell membrane protein to form bound residues which wouldexisted in animal's body for a long time with carcinogenicity andteratogenicity. In this paper，the pharmacologicaleffects and application of nitrofurazone were briefly introduced. Besides，the research progress，advantages anddisadvantages of the main methods for SEM detection，includinghigh performance liquid chromatography（HPLC）and its combined technology and immunoassay were summarized，the sources of SEM in food was also summarized，hoping to comprehensively recognize the nitrofurazone and itsmetabolite of semicarbazide，and to provide theoreticalfoundation for further research.

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