科研动态

A型塞内卡病毒（Senecavirus A，SVA）是新发现的一种影响养猪业的RNA病毒，现已在美洲的美国、加拿大、巴西、哥伦比亚以及亚洲的中国、泰国、越南等多个国家被发现。2015年SVA首次在我国广东省发现后，已有15个省、自治区和直辖市报道检测到该病毒，表明SVA已在我国不同地域广泛分布。猪感染SVA后的临床症状与口蹄疫、猪水泡病及水泡性口炎等类似，难以鉴别。SVA的实验室诊断多采用病原学和血清学方法。对于该病目前仍无商品化疫苗可用，但已有研究出重组活疫苗候选株和油佐剂灭活候选疫苗的报道。SVA未来的流行态势目前难以预测，因此需密切关注SVA在全球的流行现状，并深入研究SVA的致病及免疫机理，同时尽快研发有效的疫苗和诊断试剂。通过病原学、临床症状、流行状况、诊断方法、疫苗研发等方面的综述，本文为我国SVA防控提供了参考。

Research Progress on Senecavirus A

As an emerging RNA virus in pig industry，Senecavirus A（SVA）has been found in many countries，including the United States，Canada，Brazil，Columbia，China，Thailand，Vietnam，etc. In China，the virus has been reported by 15 provinces/autonomous regions/municipalities since 2015 when it was firstly found in Guangdong，indicating a wide prevalence in different regions. It was difficult to identify the clinical symptoms of infected pigs that were similar to those of foot-and-mouth disease，swine vesicular disease and vesicular stomatitis，hence the methods of etiology and biology were widely used by SVA detection laboratories. No any corresponding commercial vaccines were available，but recombinant live vaccine candidate strains and oil-adjuvan inactivated candidate vaccines had been developed and reported. Considering current difficulty in prediction of the development of SVA，it was necessary to pay attention to its global prevalence，and to study its pathogenesis and immune mechanism so as to develop effective vaccines and diagnostic reagents soonest. In this paper，the etiology，clinical symptoms，epidemic status，diagnostic methods，vaccine research were discussed for the purpose of providing some references for the prevention and control of SVA in China.

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