科研动态

猪流行性腹泻（PED）是由猪流行性腹泻病毒（PEDV）引起的，以腹泻为主要症状的急性肠道传染病，是长期以来危害我国养猪业健康发展的常见疾病之一。PEDV通过基因插入、缺失和重组等方式不断发生演化和变异，高致病力毒株、变异毒株不断出现，各类毒株之间的抗原性存在明显差异，导致临床上猪腹泻情况更加复杂。自2010年10月以来，由PEDV变异株引起的PED在我国大规模暴发流行，用经典毒株制备疫苗的免疫效果并不理想，因而造成重大经济损失。本文综述了PEDV在我国的流行现状及分子遗传演化特征，旨在为PED疫苗和诊断试剂研发提供参考。

Prevalence and Molecular Genetic Evolution of Porcine Epidemic Diarrhea Virus in China

Porcine epidemic diarrhea（PED）is an acute intestinal infectious disease caused by porcine epidemic diarrhea virus（PEDV）with main symptom of diarrhea，and is listed as one of common diseases endangering healthy development of China's pig industry for a long time. As PEDV has been continuously evolving and mutating through gene insertion，deletion and recombination，highly pathogenic and mutated strains are continuously appearing，and the antigenicity among various strains is obviously different，leading to the more complicated status of diarrhea in practice. Since October 2010，the outbreak of PED caused by variant strain of PEDV has widely occurred in China，which has caused huge economic losses as the vaccine prepared with the classical strain failed to effectively work. In the paper，the prevalence and molecular genetic evolution of PEDV in China were reviewed，aiming to provide a reference for future research and development of vaccines and diagnostic reagents against the virus.

原文链接：https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDAUTO&filename=ZGDW202209002&uniplatform=NZKPT&v=vPzqR5W2eDAz9hz9NoaMrO21bMUIyU67ZOM70cnUIXfMytXaGM6jTHL8ISzoY4B6